HIGH-EFFICACY LABELING OF ANTIBODIES WITH OLIGONUCLEOTIDE LABELS

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United States of America

APP PUB NO 20250011464A1
SERIAL NO

18710047

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention comprises a method for highly efficient selective labelling of antibodies with oligonucleotides. The method may involve the selective removal of glycans from the antibody and replacing them by artificial glycosides, especially N-glycosides including oligonucleotides. The process is believed to be facilitated by the oligonucleotide induced orientation of the antibody C′E loop and to a lesser extent by the Cγ2-Cγ3 domain. The method results in the high efficacy labelling of antibodies.

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Patent Owner(s)

Patent OwnerAddress
ACTOME GMBH79110 FREIBURG

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  • 2022 Application Filing Year
  • C07K Class
  • 6813 Applications Filed
  • 1104 Patents Issued To-Date
  • 16.21 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances20222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
JENEY, Csaba Freiburg, DE 7 9

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges2072101 - 1001002003004005006007008009001000110012001300140015001600170018001900200021002200

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