VASCULAR BONE ORGANOID AND ITS COMPRESSION-PERFUSION FABRICATOR SYSTEM
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United States of America
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Jan 9, 2025
app pub date -
Jul 2, 2024
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Jul 2, 2024
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Abstract
The present invention discloses a vascular bone organoid and its compression-perfusion fabricator system. The compression-perfusion fabricator system includes a compression device, a perfusion chamber, a perfusion device, and a microcomputer driver. The compression device and the perfusion device are controlled and adjusted through the microcomputer driver to simultaneously provide dynamic mechanical compression and perfusion stimulation. The system simulates the dynamic microenvironment within the human body. The present invention further utilizes 3D bioprinting technology to manufacture a vascular bone organoid, which is cultured in the compression-perfusion fabricator system, to mimic the growth of bone and vascular endothelial cells within the normal dynamic physiological environment of the bone marrow cavity.
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