DOSAGE FORM FOR INTRA-ARTICULAR INJECTION COMPRISING COLCHICINE FOR USE IN THE TREATMENT OF CRYSTAL-AND NON-CRYSTAL ASSOCIATED ACUTE INFLAMMATORY ARTHRITIS
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United States of America
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Issued Date -
Jan 9, 2025
app pub date -
Jul 12, 2022
filing date -
Jul 12, 2022
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Abstract
The present invention relates to pharmaceutical composition under the form of a suspension comprising controlled release microparticles comprising colchicine for use in the treatment of crystal-associated and non-crystal associated acute inflammatory arthritis by intra-articular injection into a joint of said pharmaceutical composition, wherein the microparticles have a mean particle size greater than 10 pm, wherein the time required to release 80% by weight of the colchicine in the microparticles is greater than 1 day and may reach 15 days, wherein the colchicine is present in a concentration ranging from 2.5 to 2500 pg per ml of suspension and wherein the pharmaceutical composition has a volume ranging from 0.1 ml to 5 ml.
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