Importance

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Abstract

A mask-based diagnostic apparatus for detecting a biomarker contained in exhaled breath of a test subject. An exhaled breath condensate (EBC) collector converts breath vapor from the lungs and airways into a fluid biosample. The EBC collector includes a condensate-forming surface and a thermal mass in thermal connection with the condensate-forming surface. A fluid transfer system transfers the EBC to at least one of a testing unit and an EBC containment vessel. Prior to testing, a semipermeable membrane concentrates a target biomarker portion in the fluid biosample to form a concentrated fluid biosample for testing. A target biomarker releasing material, such as a lysing agent, and/or mechanical lysing, can be used to obtained a target biomarker for testing that is within a viral envelope. The testing unit can be a universal g-FET biosensor constructed as a packaged semiconductor device that receives and tests the EBC as a fluid biosample.

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First Claim