Synthesis and Biological Activity of Phosphoramidimidate and Phosphoramidate DNA
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United States of America
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Dec 26, 2024
app pub date -
May 29, 2024
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May 29, 2024
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Abstract
Oligonucleotides comprising phosphoramidimidate internucleotide linkages, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous therapeutic antisense applications.
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