NOVEL COMPOUND FOR DEGRADATION OF TARGET PROTEIN OR POLYPEPTIDE BY POLYUBIQUITINATION
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United States of America
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Issued Date -
Dec 26, 2024
app pub date -
Jun 12, 2024
filing date -
Jun 12, 2024
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Abstract
Provided are a compound capable of degrading a target protein using ubiquitin and having a targeted protein binding moiety (TBM) structure binding to a target protein or polypeptide and a ubiquitin binding moiety (UBM) structure to which ubiquitin is bound, wherein the compound can be induced to polyubiquitination by the UBM structure present in the compound, and thus have an advantage of becoming a protein degrader capable of degrading a target protein or polypeptide.
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