COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2a ANTIBODIES
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United States of America
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Dec 19, 2024
app pub date -
Oct 27, 2022
filing date -
Oct 27, 2022
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Abstract
Provided are antibodies and antigen-binding fragments thereof that preferentially or selectively bind to human neuropilin-2a (NRP2a) variant 1 (v1) and/or variant 2 (v2), relative to other NRP2a isoforms or NRP2b isoforms, and which modulate binding interactions between NRP2a v1/v2 ligands and downstream signaling events. Also included are related therapeutic compositions and methods for treating diseases such as cancers and inflammatory and autoimmune diseases.
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