HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE
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United States of America
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Dec 12, 2024
app pub date -
Oct 4, 2022
filing date -
Oct 4, 2022
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Abstract
The invention provides heterobifunctional compounds comprising an effector protein binding moiety selected from GSPT1, Cyclin K, RBM23, RBM39, IKZF1, IKZF3, PLK1, CDK4 or CK1alpha which is linked to a moiety that binds to a target protein selected from KRAS, HER2, EGFR, androgen receptor protein, estrogen receptor protein, ALK, IDH1, FLT3, FGFR1, FGFR4, FGFR2, FGFR3, ERK1, ERK2, FGR, HER3 or HER4. Pharmaceutical compositions and their use in treating disease, such as cancer, are also disclosed.
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