SPATIAL METRIC MEASUREMENT METHODS FOR MULTIPLEX IMAGING AND USES IN TUMOR SAMPLE ANALYSIS
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United States of America
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Dec 5, 2024
app pub date -
May 31, 2024
filing date -
May 31, 2024
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Abstract
Spatial analysis methods based on nearest neighbor analysis are provided of specific regions of tissue to describe cancer states and develop biomarkers to predict outcomes. In various embodiments, the spatial analysis methods involve an interaction radius to computationally isolate local interactions and prevent the data from being influenced by cells that are very far away. Thereby, spatial analysis of cancer tissue can be quickly and consistently performed in an automated fashion to focus on tumor-immune cell biology, which occurs at a localized level.
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