Importance

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Abstract

A bioreactor contains one or more substrates or membranes. The membranes may be provided as part of trays having walls to contain seed cells on the membranes. Multiple trays may be formed in a stack and immersed in liquid media in the bioreactor. Gaps are provided between the trays to allow liquid media to flow horizontally into or out of the stack. Optionally, the bioreactor has an impeller configured to direct liquid media laterally. An optional cell seeding system allows a suspension of cells to be placed on a substrate while the substrate is in the bioreactor, for example via the gaps. Optionally, the bioreactor has a filtration or sorption system to remove contaminants from, or optionally add molecules, to the liquid media. The bioreactor may contain circulation and oxygenation systems to distribute gasses and nutrients as well as to remove inhibitory or toxic by-products of cellular metabolism.

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First Claim