METHOD TO OBTAIN A PURIFIED ANTIBODY COMPOSITION
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United States of America
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Issued Date -
Dec 5, 2024
app pub date -
Sep 1, 2022
filing date -
Sep 1, 2022
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Abstract
The current invention discloses a method for obtaining a purified antibody composition. The method discloses the use of various chromatography steps in a particular order to obtain a purified composition of a therapeutic monoclonal antibody starting from a composition comprising the monoclonal antibody and one or more process and product related impurities. Further, the method also discloses the use of additional purification steps such as depth filtration, diafiltration, ultrafiltration and tangential flow filtration for obtaining the said purified antibody composition.
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