COMPOUNDS TARGETING MUTANT OF P53
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United States of America
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Issued Date -
Dec 5, 2024
app pub date -
Aug 9, 2022
filing date -
Aug 9, 2022
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Abstract
Provided are compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are pharmaceutical compositions comprising the compounds, methods of preparing the compounds and the use in the manufacture of medicaments for preventing or treating a disease or condition related to p53 mutants.
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