CHIMERIC ANTIGEN RECEPTOR AND CELL INCLUDING CHIMERIC ANTIGEN RECEPTOR
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United States of America
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Dec 5, 2024
app pub date -
Sep 14, 2023
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Sep 14, 2023
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Abstract
The present disclosure provides chimeric antigen receptor (CAR) for Human C-type lectin-like molecule-1 (CLL-1) comprising a polypeptide comprising: an extracellular antigen binding domain comprising an anti-CLL-1 single heavy chain variable domain (VH) and anti-CLL-1 single light chain variable domain (VL); a transmembrane domain; and an intracellular signaling domain. Immune effector cells comprising the CAR and pharmaceutical compositions based on the immune effector cells, as well as their therapeutic use in treating condition associated with CLL-1, are also disclosed.
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