Microfluidic Magnetic Separation Device with A Magnetophoretic Gradient for Isolation of Target Cell Populations from Fluid Samples
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United States of America
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Nov 28, 2024
app pub date -
Sep 20, 2022
filing date -
Sep 20, 2022
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Devices, methods, and kits are provided for isolating a target cell from a fluid sample. In particular, a magnetophoretic separation device is provided that applies varying magnetic field strength to flowing magnetically tagged cells. Immunomagnetic negative selection of target cells is used to maintain target cells in their native, unlabeled state. The magnetophoretic separation device is suitable for isolating cells from low volumes of whole blood, which provides an advantage over in-bulk methods that require larger starting volumes of blood. A computer implemented method is also provided for producing target magnetophoretic profiles along the path through which cells travel through a fluidic conduit in the device that is adaptable to a variety of form factors.
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