ENZYMES, HOST CELLS, AND METHODS FOR BIOSYNTHESIS OF DAMMARENEDIOL AND DERIVATIVES
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United States of America
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Nov 28, 2024
app pub date -
Sep 9, 2022
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Sep 9, 2022
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The disclosure provides compositions and methods related to engineered microbial cells, enzymes, and methods for producing dammarenediol, as well as compounds derived from dammarenediol. Microbial host cells are engineered to express a heterologous biosynthetic pathway that produces dammarenediol, or a derivative thereof. The host cell can optionally express a heterologous uridine diphosphate-dependent glycosyltransferase (UGT) enzyme producing natural or non-natural glycosylated forms of dammarenediol, protopanaxadiol or protopanaxatriol.
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