HIGH CONCENTRATION ANTIBODY-CONTAINING LIQUID FORMULATION

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United States of America

APP PUB NO 20240392017A1
SERIAL NO

18792080

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Abstract

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The problem to be solved is to provide a humanized anti-IL-6 receptor antibody MRA-containing formulation which is suitable for subcutaneous administration, wherein dimerization or deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and histidine buffer. A method of inhibiting deamidation or dimerization of such an antibody in a concentrated liquid formulation includes histidine buffer in the liquid formulation.

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Patent Owner(s)

Patent OwnerAddress
HOFFMANN-LA ROCHE INCGREAT NOTCH 150 CLOVE ROAD 8TH FLOOR LITTLE FALLS NJ 07424

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
IMAEDA, Yoshimi Tokyo, JP 13 214
KAMEOKA, Daisuke Tokyo, JP 22 438
MAEDA, Terutoshi Tokyo, JP 11 136
MORICHIKA, Toshiyuki Tokyo, JP 13 284
STAUCH, Oliver Boris Freiburg, DE 29 447

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