PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS

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United States of America

APP PUB NO 20240391922A1
SERIAL NO

18775532

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Abstract

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The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

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Patent Owner(s)

Patent OwnerAddress
NOVO NORDISK HEATHCARE AGNot Provided

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ericsson, Anna Shrewsbury, US 62 1066
Green, Neal Newton, US 23 219
Gustafson, Gary Hilton Head Island, US 57 965
Han, Bingsong Westwood, US 96 1666
Lancia,, JR David R Westwood, US 130 2350
Mitchell, Lorna Cambridge, US 24 190
Richard, David Littleton, US 42 232
Shelekhin, Tatiana Ridgefield, US 25 123
Smith, Chase C Rutland, US 27 311
Wang, Zhongguo Lexington, US 77 1067
Zheng, Xiaozhang Lexington, US 158 2458

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