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Abstract

Near-infrared fluorescent dye-loaded microspheres and a formulation thereof that include a complex of a near-infrared fluorescent dye and human serum albumin or cyclodextrin loaded into polymer microspheres, optionally with a hydrogel polymer. The near-infrared fluorescent dye-loaded microspheres are used in a method of marking lesions for accurately identifying the location of lesion sites from fluorescence imaging during surgery. The method involves injecting the microspheres into lesion sites in a subject, such as cancer. The intensity of fluorescence generated from the microspheres is stronger than that when microspheres are prepared using a near-infrared fluorescent dye alone, the stability of the fluorescent dye in the microspheres is improved, and the marked sites can be identified through fluorescent imaging for a long period of time, increasing the accuracy of surgery for lesion excision, and shortening the time required for surgery.

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First Claim