APPLICATION OF CHANNEL BLOCKER IN PREPARATION OF DRUGS FOR TREATING AND/OR PREVENTING LIVER FIBROSIS
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United States of America
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Nov 28, 2024
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Sep 6, 2023
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Sep 6, 2023
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Abstract
An application of a channel blocker in preparation of drugs for treating and/or preventing liver fibrosis is provided, belonging to the field of biomedical technology. A new use of phenytoin sodium is provided. It is demonstrated that at the cell level, the phenytoin sodium can improve liver fibrosis by regulating autophagy and thus affecting the activation of hepatic stellate cells. In this situation, the efficacy of the phenytoin sodium on liver fibrosis is verified at the animal level by establishing a disease model, and the phenytoin sodium can be used to prepare drugs for treating and/or preventing liver fibrosis.
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