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Abstract

This disclosure provides techniques and systems for using a neuronal cell culture such as an organoid as a compute substrate. The cell culture is communicatively connected to an electronic computing device that provides input signals and receives output signals from the cell culture. The connection may be implemented, for example, with a multi-electrode array (MEA). The neuronal cell culture may function as a reservoir in reservoir computing. The neuronal cell culture when functioning as a reservoir provides a fixed, non-linear system that receives inputs and generates outputs. The neuronal cell culture may also function as a spiking neural network (SNN) where the neurons are nodes and the activation potentials are spikes. Neuronal cell cultures provide compute substrates that are energy efficient, cost-effective to manufacture, biodegradable, and adaptable.

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First Claim