SMALL MOLECULE BTK DEGRADERS AND METHODS OF USE THEREOF
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United States of America
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Nov 21, 2024
app pub date -
May 15, 2024
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May 15, 2024
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Abstract
Novel small molecule proteolysis-targeting chimeras (PROTACs) are provided, along with methods for their use as Bruton's tyrosine kinase (BTK) degraders. The small molecule PROTACs described herein are useful in treating and/or preventing BTK-related diseases, such as cancer, neurodegenerative disorders, inflammatory diseases, and metabolic disorders. Also provided are methods for inducing BTK degradation in a cell using the compounds and compositions described herein.
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