Target Initiation and Amplification of Long DNA with Nuclease and Replisome Enzymes
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United States of America
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Nov 14, 2024
app pub date -
Jun 9, 2022
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Jun 9, 2022
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Abstract
Compositions, methods and kits are provided for long range amplification of nucleic acid sequences in vitro. This includes a site-specific or sequence-specific nick in one strand of a duplex to initiate strand displacement linear amplification without the need for primers. Preferably, modified components of a T7 replisome are used for the in vitro linear amplification reaction enabling copying of at least 300 bases and as much as 50 kb of the target nucleic acid.
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