Method To Control High Molecular Weight Aggregates In An Antibody Composition
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United States of America
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Nov 14, 2024
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Jul 27, 2022
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Jul 27, 2022
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Abstract
The method disclosed in the current invention is used to purify an antibody from high molecular weight aggregates. The method discloses the use of anion exchange chromatography for the reduction of high molecular weight aggregates from the antibody composition, in particular, by contacting the antibody composition with the anion exchange resin at a specific pH and conductivity. The disclosed method eliminates the need for further chromatographic steps for the reduction of HMW aggregates.
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