PURIFICATION OF ANTIBODIES BY MIXED MODE CHROMATOGRAPHY
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United States of America
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Nov 14, 2024
app pub date -
Sep 29, 2023
filing date -
Sep 29, 2023
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Abstract
Herein is reported a method for producing or purifying an antibody using a mixed mode chromatography material that comprises ion exchange functional groups and hydrophobic interaction functional groups (MM HIC/TEX) operated in flowthrough mode, wherein the antibody is a hydrophilic antibody, and the antibody is applied in a solution comprising the antibody and an antichaotropic salt to the MM HIC/IEX chromatography material.
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