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Abstract

This disclosure relates more particularly to risk assessment of autism spectrum disorder (ASD) present in the subject and designing a personalized recommendation for the same. Current diagnostic tools and procedures, though abundant in numbers, are all based on psychiatric or behavioral evaluations, checklists and associated statistical inferences, which highlight the inherent limitation in making a reliable and early diagnosis. The present disclosure makes use of oral microbial samples of both saliva and dental plaque. The present disclosure involves a paired extraction and quantification of site-specific unique microbial sequences pertaining to the oral microbial samples of an ASD subject and subsequent classification of the subject under the ASD risk category using a metric based on a predefined ensemble of mathematical formulas. Further, a guided development of personalized microbial cocktail(s) is then designed based on the most relevant formula-set for the subject.

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