PEPTIDE COMPOUND PRODUCTION METHOD AND AMIDATION AGENT
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United States of America
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Issued Date -
Nov 7, 2024
app pub date -
May 25, 2022
filing date -
May 25, 2022
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Abstract
The present invention provides a method for inexpensively and efficiently synthesizing polypeptide compounds comprising various amino acids. The method involves (i) inducing an amide formation reaction between the carboxyl group on the right side in the formula of the amino acid or peptide compound represented by formula (R1) and the amino group on the left side in the formula of the amino acid ester or peptide ester compound represented by formula (R2) in the presence of an aluminum compound represented by formula (A) to obtain a peptide compound represented by formula (P1) (the definitions of the reference signs in the formula are as presented in the description).
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