POLYMER-TEMPLATED HYDROXYAPATITE AND USES THEREOF FOR PURIFICATION OF TARGET MOLECULES
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United States of America
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Issued Date -
Nov 7, 2024
app pub date -
May 2, 2024
filing date -
May 2, 2024
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Abstract
Provided herein is a chromatography media composed of a particulate substrate (such as beads or other particulate substrates) that is coated with hydroxyapatite (HA) and in which the particulate substrate used as the base upon which calcium phosphate (CaP) is formed is treated with heat to remove the substrate, convert the CaP to HA, and form the desired HA microstructure so as to form a templated porous HA substrate (TPHA substrate). Also provided is a chromatography media (optionally contained within a column) comprising a TPHA substrate (e.g., a plurality of TPHA particles). The TPHA particles are porous or macroporous and uses thereof.
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