HUMAN TRANSFERRIN RECEPTOR BINDING ANTIBODY-PEPTIDE CONJUGATE
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United States of America
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Issued Date -
Nov 7, 2024
app pub date -
Aug 24, 2022
filing date -
Aug 24, 2022
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Abstract
The technic to pass through the blood-brain barrier is provided. A conjugate comprising:
- (1) a peptide that binds to a transferrin receptor, wherein the peptide is: (i) a peptide comprising 1st to 15th amino acid sequence (Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Arg-Arg-Tyr-MeY-Cys) of an amino acid sequence described in SEQ ID NO: 1;(ii) a peptide comprising an amino acid sequence having substitution, deletion, addition and/or insertion of 1 to 11 amino acid residues in the 1st to 15th amino acid sequence of the amino acid sequence described in SEQ ID NO: 1;(iii) a peptide comprising 1st to 12th amino acid sequence (Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Ser-Cys) of an amino acid sequence described in SEQ ID NO: 14; or(iv) a peptide comprising an amino acid sequence having substitution, deletion, addition and/or insertion of 1 to 8 amino acid residues in the 1st to 10th amino acid sequence of the amino acid sequence described in SEQ ID NO: 14, and (2) a compound comprising an antibody or an antigen-binding fragment thereof.
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