SYSTEMS AND METHODS OF IMPEDANCE-BASED BIOMASS SENSING IN FIXED BED BIOREACTORS
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United States of America
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Issued Date -
Oct 31, 2024
app pub date -
Apr 26, 2024
filing date -
Apr 26, 2024
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Abstract
A cell culture bioreactor is disclosed that has a cell culture vessel with an interior reservoir to contain a cell substrate, an inlet fluidly connected to the reservoir, and an outlet fluidly connect to the reservoir. The bioreactor also has a sensor system for measuring impedance within the reservoir. The sensor system includes a pair of electrodes that are spaced apart from each other with at least a portion of the cell substrate disposed between the pair of electrodes. Each electrode of the pair of electrodes includes a plurality of pores to allow at least one of cells and culture media to flow through the electrode.
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