BLOOD BRAIN BARRIER PENETRATING SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF
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United States of America
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Oct 31, 2024
app pub date -
Mar 11, 2024
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Mar 11, 2024
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Abstract
The present invention relates to novel blood-brain barrier (BBB) penetrable substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions.
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