MULTIPLEX, TEMPORALLY RESOLVED MOLECULAR SIGNAL RECORDER AND RELATED METHODS
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United States of America Patent
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Issued Date -
Oct 24, 2024
app pub date -
Sep 1, 2022
filing date -
Sep 1, 2022
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Abstract
Embodiments of the present disclosure provide composition and methods for recording an iterative nucleic acid editing event. The compositions and methods described herein comprise a first active target domain, comprising an editable recording sequence configured to hybridize with a first prime editing guide RNA (pegRNA) and one or more inactive truncated target domains comprising a non-editable sequence configured to not hybridize with the pegRNA, wherein the first pegRNA edits the first active target domain, wherein the pegRNA edit shifts the position of the recoding sequence from the editable sequence to the non-editable sequence, thereby changing the editable sequence to a non-editable sequence and the inactive truncated target domain to a second active target domain comprising a second recoding sequence configured to hybridize with a second pegRNA.
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