CELLS COMPRISING MOGROSIDE PATHWAY ENZYMES AND USES THEREOF
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United States of America Patent
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Issued Date -
Oct 24, 2024
app pub date -
Jun 28, 2024
filing date -
Jun 28, 2024
priority date (Note) -
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status (Latency Note)
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Abstract
Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), expoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT), Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside. Alternatively or additionally provided is a method of synthesizing a mogrol, the method comprising contacting a mogrol precursor substrate with one or more mogrol biosynthetic pathway enzyme polypeptides as described herein catalyzing mogrol synthesis from the mogrol precursor substrate, thereby synthesizing the mogrol.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) | VOLCANI CENTER P O BOX 15159 RISHON-LEZION 7528809 |
International Classification(s)

- 2024 Application Filing Year
- C12P Class
- 496 Applications Filed
- 23 Patents Issued To-Date
- 4.64 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
BURGER, Yosef | Haifa, IL | 6 | 21 |
# of filed Patents : 6 Total Citations : 21 | |||
COHEN, Shahar | Rishon-LeZion, IL | 29 | 101 |
# of filed Patents : 29 Total Citations : 101 | |||
DAVIDOVICH-RIKANATI, Rachel | Alonei Abba, IL | 4 | 8 |
# of filed Patents : 4 Total Citations : 8 | |||
DORON-FAIGENBOIM, Adi | Tel Aviv-Yafo, IL | 4 | 8 |
# of filed Patents : 4 Total Citations : 8 | |||
ITKIN, Maxim | Kibbutz HaOgen, IL | 14 | 69 |
# of filed Patents : 14 Total Citations : 69 | |||
KATZIR, Nurit | Kiryat-Tivon, IL | 6 | 21 |
# of filed Patents : 6 Total Citations : 21 | |||
LEWINSOHN, Efraim | Timrat, IL | 10 | 18 |
# of filed Patents : 10 Total Citations : 18 | |||
OREN, Elad | Beit Shearim, IL | 51 | 218 |
# of filed Patents : 51 Total Citations : 218 | |||
PETREIKOV, Marina | Rishon-LeZion, IL | 9 | 8 |
# of filed Patents : 9 Total Citations : 8 | |||
PORTNOY, Vitaly | Nesher, IL | 26 | 51 |
# of filed Patents : 26 Total Citations : 51 | |||
SCHAFFER, Arthur Aaron | Hashmonaim, IL | 1 | 0 |
# of filed Patents : 1 Total Citations : 0 | |||
SHEN, Shmuel | Moshav Beit-Elazari, IL | 3 | 8 |
# of filed Patents : 3 Total Citations : 8 | |||
TADMOR, Yaakov | Timrat, IL | 6 | 22 |
# of filed Patents : 6 Total Citations : 22 |
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Patent Citation Ranking
- 0 Citation Count
- C12P Class
- 0 % this patent is cited more than
- 1 Age
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