CELLS COMPRISING MOGROSIDE PATHWAY ENZYMES AND USES THEREOF

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United States of America Patent

APP PUB NO 20240352501A1
SERIAL NO

18757644

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Abstract

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Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), expoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT), Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside. Alternatively or additionally provided is a method of synthesizing a mogrol, the method comprising contacting a mogrol precursor substrate with one or more mogrol biosynthetic pathway enzyme polypeptides as described herein catalyzing mogrol synthesis from the mogrol precursor substrate, thereby synthesizing the mogrol.

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Patent Owner(s)

Patent OwnerAddress
THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER)VOLCANI CENTER P O BOX 15159 RISHON-LEZION 7528809

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  • 2024 Application Filing Year
  • C12P Class
  • 496 Applications Filed
  • 23 Patents Issued To-Date
  • 4.64 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BURGER, Yosef Haifa, IL 6 21
COHEN, Shahar Rishon-LeZion, IL 29 101
DAVIDOVICH-RIKANATI, Rachel Alonei Abba, IL 4 8
DORON-FAIGENBOIM, Adi Tel Aviv-Yafo, IL 4 8
ITKIN, Maxim Kibbutz HaOgen, IL 14 69
KATZIR, Nurit Kiryat-Tivon, IL 6 21
LEWINSOHN, Efraim Timrat, IL 10 18
OREN, Elad Beit Shearim, IL 51 218
PETREIKOV, Marina Rishon-LeZion, IL 9 8
PORTNOY, Vitaly Nesher, IL 26 51
SCHAFFER, Arthur Aaron Hashmonaim, IL 1 0
SHEN, Shmuel Moshav Beit-Elazari, IL 3 8
TADMOR, Yaakov Timrat, IL 6 22

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges377110801 - 1002505007501000125015001750200022502500275030003250350037504000

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