POLYNUCLEOTIDES ENCODING NOVEL NUCLEASES, COMPOSITIONS THEREOF AND METHODS THEREOF FOR ELIMINATING DNA FROM PROTEIN PREPARATIONS
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United States of America Patent
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Issued Date -
Oct 24, 2024
app pub date -
Aug 19, 2022
filing date -
Aug 19, 2022
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Abstract
The instant disclosure provides, among other things, novel nuclease proteins (enzymes), novel nuclease compositions and protein preparations thereof, recombinant polynucleotides (DNA) encoding such nuclease proteins, recombinant host cells expressing and producing one or more nuclease proteins (optionally co-expressing one or more proteins of interest) and the like. More particularly, the nuclease proteins (enzymes) of the instant disclosure are particularly useful in mitigating DNA contamination, such as contaminating DNA present in a fermentation broth in which microbial host cells have been fermented, contaminating DNA present in recovered proteins of interest, contaminating DNA present in protein preparations, and the like.
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