ENGINEERED BACTERIA FOR BIOSYNTHESIS OF PEPTIDE-BASED QUORUM SENSING INHIBITORS
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Oct 24, 2024
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Feb 16, 2024
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Feb 16, 2024
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Described herein are engineered bacterial cells capable of producing an autoinducing peptide (AIP) or non-native AIP analog (including AIP inhibitors), methods for producing the AIP or non-native AIP analog, plasmids and kits. The bacterial cells are transformed with at least one plasmid into gram-positive bacterial cells expressing a mutation in the argD gene manipulating the AIP biosynthesis system via the AgrB/D to produce inhibitors of the S. aureus arg quorum sensing.
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