NOVEL PYRIMIDINE-2,4-DIAMINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER

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United States of America Patent

APP PUB NO 20240352000A1
SERIAL NO

18579279

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Abstract

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The present invention relates to a pyrimidine-2,4-diamine derivative, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer, comprising the same as an active ingredient. The pyrimidine-2,4-diamine derivative exhibits a high inhibitory ability against EGFR and HER2 mutations, and thus can be advantageously used in the treatment of cancer in which EGFR and HER2 mutations have occurred. In addition, the pyrimidine-2,4-diamine derivative exhibits a significant synergistic effect when administered in combination, and thus may be advantageously used in combination therapy.

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Patent Owner(s)

Patent OwnerAddress
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYDAEJEON 305-606

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHAE, Chong Hak Daejeon, KR 14 19
CHO, Byoung Chul Seoul, KR 14 26
CHOI, Gildon Daejeon, KR 15 5
DUGGIRALA, Krishna Babu Daejeon, KR 5 2
JUNG, Myoung Eun Daejeon, KR 5 2
LEE, Kwangho Daejeon, KR 61 625
LEE, Yujin Gimcheon-si, Gyeongsangbuk-do, KR 75 363

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