METHODS FOR CREATING REGULATORY T CELLS (TREGS) USING GENOME ENGINEERING
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Oct 24, 2024
app pub date -
Mar 20, 2024
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Mar 20, 2024
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Abstract
Provided are methods, polynucleotides and compositions for the generation of engineered Treg cells. The methods, polynucleotides and compositions enable the reprogramming of hematopoietic cells into Treg cells by constitutive or regulated expression of FOXP3 in engineered cells such that the engineered Treg cells can suppress the activation and proliferation of responder T cells.
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