IMPROVEMENTS IN OR RELATING TO A METHOD OR AN APPARATUS FOR DETECTING AN INTERACTION BETWEEN A BIOLOGICAL ENTITY AND A MOLECULE
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United States of America Patent
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Issued Date -
Oct 17, 2024
app pub date -
Jul 8, 2022
filing date -
Jul 8, 2022
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Abstract
A method of detecting the interactions between a biological entity and a molecule, the method comprising providing an array of first microdroplets into a microfluidic chip; wherein each microdroplet contains at least one bead and each bead having a bound photocleavable molecule; providing an array of second microdroplets into the microfluidic chip; wherein each microdroplet contains at least one biological entity; holding the entire first and second arrays of microdroplets; illuminating at least a subset of the first microdroplets containing at least one bead with an illumination source configured to photo-cleave the molecule; subsequently merging at least one subset of the first array of microdroplets with at least one subset of the second microdroplets to form an array of merged microdroplets; and detecting a change in an optical signal from the merged microdroplets using an optical system to indicate the interactions between the biological entity and the molecule. An apparatus for detecting the interaction between a biological entity and a molecule is also provided.
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