STABLE ISOQUINOLINE-CORTICOSTEROID CONJUGATES AND USES THEREOF
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United States of America Patent
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Issued Date -
Oct 17, 2024
app pub date -
Apr 29, 2022
filing date -
Apr 29, 2022
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Abstract
Provided herein are compounds and pharmaceutical compositions useful in modulating kinase activity, and related diseases. These compounds are conjugates of glucocorticoids with rho-kinase inhibitors. Also provided herein are methods of treating an eye disease or disorder in a subject. Also provided herein are methods of reducing intraocular pressure in a subject. Also provided herein are methods of modulating kinase activity in a cell. Also provided herein are methods of making the compounds provided herein, and compounds useful for the preparation of the compounds provided herein.
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