ASYMMETRIC GPR84 ANTAGONIST AND USE THEREOF
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United States of America Patent
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Oct 17, 2024
app pub date -
Jul 13, 2022
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Jul 13, 2022
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Abstract
An asymmetric GPR84 antagonist and a use thereof, the GPR84 antagonist having a structure as shown in formula I. The compound represented by formula I has GPR84 antagonistic activity, can competitively inhibit GPR84 agonist-induced receptor activation, and can be used to treat various diseases associated with the high expression or hyperexcitability of GPR84, such as multiple sclerosis, inflammatory bowel disease, organ fibrosis, arthritis, etc.
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