PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES
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United States of America Patent
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Oct 10, 2024
app pub date -
Apr 4, 2024
filing date -
Aug 2, 2022
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Abstract
Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
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