MODIFIED PRODUCER CELLS FOR EXTRACELLULAR VESICLE PRODUCTION
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United States of America Patent
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Oct 10, 2024
app pub date -
Oct 14, 2022
filing date -
Oct 14, 2021
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Abstract
The present disclosure provides methods of producing extracellular vesicles and methods of increasing extracellular vesicle production from producer cells, which exhibit a reduced gene and/or protein function in a cholesterol biosynthetic pathway. Also provided are cell compositions having a reduced gene and/or protein function in a cholesterol biosynthetic pathway. Reducing gene and/or protein function in a cholesterol biosynthetic pathway increases the yield and production of extracellular vesicles from the producer cells.
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