POST-TRANSLATIONAL MODIFICATION CHIMERIC MOLECULE
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Issued Date -
Oct 10, 2024
app pub date -
Apr 4, 2024
filing date -
Apr 4, 2023
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Abstract
In one or more aspects, the inventions described herein are directed to chimeric molecules and methods of making the same that provide improved protein modulating processes including, but not limited to, ubiquitination/deubiquination, lipidation/delipidation, SUMOylation/deSUMOylation, nitrosylation/denitrosylation, phosphporylation/dephosphorylation, acetylation/deacetylation, alkylation/dealklyation, methylation/demethylation, carboxylaton/decarboxylation, glycoysylation/deglycoylation, hydroxylation/dehydroxylation, and disulfide bond formation and breakage. In particular, the present disclose provides chimeric molecules including (i) a post-translational modifications (PTMs) domain and (ii) a targeting domain comprising a substrate-binding motif which is heterologous to the PTMS domain, and (iii) a linker that couples the PTMS domain to the targeting domain.
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