HIGH-AFFINITY SUPRAMOLECULAR POLYMERS FOR BINDING-TRIGGERED ANTIBODY PRECIPITATION AND PURIFICATION
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United States of America Patent
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Issued Date -
Oct 3, 2024
app pub date -
Jul 18, 2022
filing date -
Jul 20, 2021
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Abstract
The disclosure is directed to systems and methods for purifying proteins containing an Fc region, such as antibodies or Fc fusion proteins. The system includes one or more filler molecules comprising a linear hydrocarbon chain conjugated to a peptide amino acid sequence, and one or more ligand molecules comprising a linear hydrocarbon chain, a peptide amino acid sequence, a linker, and a Z33 peptide of Staphylococcus aureus Protein A. The filler molecules and ligand molecules self-assemble into immunofibers (IFs) under physiological conditions.
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