METHOD FOR PURIFYING PROTEINS
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United States of America Patent
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Issued Date -
Oct 3, 2024
app pub date -
Feb 15, 2024
filing date -
Dec 18, 2018
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Abstract
The invention pertains to methods of purifying fusion proteins, in particular TNFR:Fc fusion proteins. Methods disclosed herein can be used to produce highly pure TNFR:Fc fusion proteins (e.g., etanercept) having a biological activity by removing hard to separate product related impurities such as clipped and/or mis-fold/aggregated TNFR:Fc fusion proteins.
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