PROCESS FOR PURIFICATION OF PROTEIN

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United States of America Patent

APP PUB NO 20240317799A1
SERIAL NO

18620441

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to purification process of pharmacologically active IgG1 containing protein comprising at least affinity chromatography followed by mixed-mode chromatography. The present invention provides cytotoxic T-lymphocyte-associated 4-immunoglobulin (CTLA4-Ig) fusion protein by using at least affinity chromatography, mixed-mode chromatography and optionally one or more suitable purification steps that provides purified composition of the fusion protein, substantially free of impurities selected from Pre-Peak, product and process related impurities. Further, the present invention provides highly purified CTLA4-Ig fusion protein with reduced heterogeneity.

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ACQUIOM AGENCY SERVICES LLC AS COLLATERAL AGENT950 17TH STREET SUITE 1400 DENVER CO 80202

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gupta, Tarun Kumar Ahmedabad, IN 11 0
Narayan, Om Ahmedabad, IN 15 0
Thakkar, Mayankkumar Ahmedabad, IN 11 0
Upadhyay, Roshan Ganeshlal Ahmedabad, IN 6 0

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges585812301 - 100500100015002000250030003500400045005000550060006500

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