TREATMENT OF CONGENITAL HYPERINSULINISM WITH AVEXITIDE
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United States of America Patent
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Issued Date -
Sep 19, 2024
app pub date -
Jun 21, 2022
filing date -
Jun 21, 2021
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Abstract
Methods of treating congenital hyperinsulinism (CHI) are provided. In particular, the present disclosure provides for treatment of CHI by administering avexitide to a subject having CHI. The provided methods can involve subcutaneously administering avexitide to a subject having CHI. In some instances, a reduction in the glucose infusion rate (GIR) necessary to maintain euglycemia in the subject is achieved by administering avexitide to the subject. In some instances, administering avexitide reduces the hypoglycemia event rate in a subject having CHI.
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