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Abstract

Disclosed are novel compositions, methods to improve a suboptimal therapeutic agent's performance in patients with cancer, infections, inflammatory, metabolic, immunological diseases. Describe are improvements ranging from pharmaceutical ingredients, dosage forms, excipients, solvents, diluents, drug delivery systems, preservatives, more accurate drug administrations, dose determination/schedules, toxicity monitoring and amelioration, techniques or agents. Using suboptimal therapeutic(s)s in conjunction with radiation(s) and/or conventional chemotherapeutic agent(s)s or biotherapeutic agent(s) including antibodies, vaccines, cytokines, lymphokines, gene and antisense RNA therapies, etc., would provide unique approaches, significant treatment improvement circumventing or reducing toxicity, including techniques and tools identifying/predicting patients by phenotype or genotype determination(s). The disclosed invention also relates to using novel prodrugs, polymer conjugates, novel routes of administration, other agents to potentiate activity of the compound(s) or inhibit repair of suboptimal cellular effects or sublethal damage or to “push” the cell into more destructive cellular phases such as immune stimulation and apoptosis.

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First Claim