OPTICAL SYSTEMS AND METHODS OF PROBING BIOLOGICAL FLUIDS
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United States of America Patent
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Issued Date -
Sep 12, 2024
app pub date -
Jun 2, 2023
filing date -
Mar 10, 2023
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Abstract
A system and method for determining a viscosity of a fluid medium containing a fluorescent species, including a light source exciting the fluorescent species at an excitation area of the fluid medium to produce a fluorescent signal and photobleaching the fluorescent species, and the fluorescent species diffusing in and out of the excitation area of the fluid medium at a rate determined by an excitation geometry of the light source, a diffusivity of the fluorescent species, and the viscosity of the fluid medium; and a detector detecting the fluorescent signal over time to generate a fluorescence decay curve of the fluorescent species in the fluid medium, where the viscosity of the fluid medium is determined based on a numerical comparison of the fluorescence decay curve of the fluorescent species in the fluid medium with a fluorescence decay curve of the fluorescent species in a reference medium of known viscosity.
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