ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGS

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United States of America Patent

APP PUB NO 20240301460A1
SERIAL NO

18675302

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Abstract

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The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campos, Kevin R Berkeley Heights, US 12 9
Devine, Paul N Tinton Falls, US 32 139
Fryszkowska, Anna Scotch Plains, US 23 11
Huffman, Mark A Warren, US 20 84
Kolev, Joshua N Califon, US 7 2
Nawrat, Christopher C Garwood, US 2 0
Truppo, Matthew Princeton, US 6 4

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