CLY SERIES COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF DRUGS
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United States of America Patent
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Issued Date -
Sep 12, 2024
app pub date -
Jun 17, 2022
filing date -
Jun 17, 2021
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Disclosed a CLY series compound, a preparation method therefor and the use thereof in the preparation of drugs. The CLY series compound can significantly prolong the survival time of acute GVHD mice, and can reduce clinical symptoms, exhibiting a therapeutic effect on acute GVHD; in a pulmonary fibrosis mouse model, same can obviously reduce the levels of MMP-2 and MMP-9 in the lung tissue, increase the levels of TIMP-1 and VEGF, and simultaneously increase the levels of SOD and CAT enzymes in peripheral blood; and same can also improve the arthritis symptoms of rheumatoid arthritis mice by means of reducing the level of IL-17 in peripheral blood and increasing inflammatory indexes such as IL-10. The compound can be used alone or in combination with other drugs, and provides a new drug choice for the treatment of the above diseases.
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